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Model Introduction
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Hormonal femoral head necrosis model
Steroids-induced osteonecrosis of the femoral head (SONFH) is a metabolic disease caused by the use of glucocorticoids, due to the use of glucocorticoid drugs, resulting in impaired blood supply to the femoral head, the death of osteoblasts and bone marrow components, which leads to structural changes in the femoral head, collapse and joint dysfunction.
Prednisolone acetate or dexamethasone
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Large bone disease model
Osteoarthritis is a chronic endemic disease characterized by multiple, focal necrosis of medullary plate cartilage and articular cartilage of unknown cause. Some studies have suggested that the cause of the disease is selenium deficiency or T-2 toxin poisoning.T-2 toxin mainly harms human cartilage, leading to the occurrence of osteoarthritis, which is characterized by joint enlargement and limited movement in mild cases, and short limb deformity and disability in severe cases.
T-2 toxin
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Osteoporosis model 01
Osteoporosis (OP) has become one of the chronic diseases that seriously threaten human health, and with the aging of our population, osteoporosis will become a social problem. Selecting and establishing an appropriate osteoporosis animal model is a prerequisite for osteoporosis research. There are many methods of osteoporosis modeling, such as ovariectomy, retinoic acid method, glucocorticoid method, etc. Although ovariectomized rats are the “gold standard” for postmenopausal osteoporosis research, they also have drawbacks (no Harvard's reconstruction, can't be used to study the changes of cortical bone).
Retinoic acid
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Osteoporosis model 02
Osteoporosis (OP) has become one of the chronic diseases that seriously threaten human health, and with the aging of our population, osteoporosis will become a social problem. Selecting and establishing an appropriate osteoporosis animal model is a prerequisite for osteoporosis research. There are many methods of osteoporosis modeling, such as ovariectomy, retinoic acid method, glucocorticoid method, etc. Although ovariectomized rats are the “gold standard” for postmenopausal osteoporosis research, they also have drawbacks (no Harvard's reconstruction, can't be used to study the changes of cortical bone).
Glucocorticoid
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Sarcopenia model
Sarcopenia is a geriatric syndrome of ageing-related loss of muscle mass, loss of muscle strength, and/or reduced somatic function. As a muscle physiologic dysfunction disorder, sarcopenia is one of the important extrapulmonary complications of chronic obstructive pulmonary disease (COPD), which is mainly characterized by a decrease in muscle content/strength throughout the body.
Dexamethasone/D-Galactose
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