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Endometrial adenomyosis model
Adenomyosis refers to the presence of ectopic, non-neoplastic endometrial glands and mesenchyme in the myometrium. Following trauma at the endometrial-myometrial interface, increased peristalsis in the junctional zone activates local trauma and repair processes, allowing estradiol levels to rise, which prompts epithelial mesenchymal transformation and subsequently permits endometrial invasion of the myometrium.
Toremifene
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Hyperprolactinemia model
Hyperprolactinemia (HPRL) is one of the most important causes of female infertility.HPRL is a condition in which peripheral blood prolactin levels are persistently higher than normal due to various reasons.HPRL is characterized by endocrine disorders of the hypothalamic-pituitary-gonadal axis, and it occurs more often in female patients, with clinical manifestations such as irregular menstruation, infertility, breast enlargement, and breast milk overflow, The main clinical manifestations are menstrual disorders and infertility, breast enlargement, breast overflow, decreased bone density, and symptoms of anterior pituitary adenoma compression such as headache and vision loss.
Metopramide
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Breast fibrocystic hyperplasia model
The etiology of fibrocystic disease of breast (FBD) is not completely clear so far may be mainly related to ovarian endocrine disorders, absolute or relative increase in estrogen secretion, and continuous estrogen stimulation of mammary epithelial cell hyperplasia, which was modeled by the addition of estrogenic feed.
Estradiol valerate
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Hyperuric acid erectile dysfunction model
Erectile dysfunction (ED) is the physical inability to have an erection, or an erection that does not last long enough for a satisfying sexual experience. Usually, the factors that lead to ED are complex and numerous, such as high blood pressure, diabetes and kidney failure. Some studies have shown that the development of ED is influenced by the body's high uric acid (UA) levels.
Yeast powder, ethambutol and potassium oxonate
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Hypertensive erectile dysfunction model
Erectile dysfunction (ED) is the physical inability to have an erection, or an erection that does not last long enough for a satisfying sexual experience. Often, the causes of ED are complex and varied, such as high blood pressure, diabetes, and kidney failure.
N-Nitro-L-arginine methyl ester (L-NAME)
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Uterine fibroid model
Uterine fibroids are one of the most common benign tumors of the female reproductive system, occurring in women of childbearing age with strong secretion of sex hormones. After menopause, the development of fibroids stops or shrinks, and they are often characterized by abdominal pain, increased menstrual flow, prolonged menstruation, shortened menstrual cycle, anemia, preterm labor, abortion, infertility, and compression of the rectum or bladder as clinical manifestations. The model was constructed by adding estrogen to the feed.
Estradiol valerate
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Intrahepatic cholestasis of pregnancy model
Intrahepatic cholestasis of pregnancy (ICP) is an obstetric disease characterized by pruritus, jaundice, and hepatic impairment at the end of pregnancy. It causes amniotic fluid contamination, intrauterine distress, preterm labor, stillbirth, and other serious health hazards to mothers and babies. At the same time, due to the bile secretion and excretion obstacles, resulting in increased bilirubin, liver cell lesions or necrosis, resulting in cholestatic liver injury.
Estradiol valerate
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Pregnancy-induced hypertension model
Hypertension in pregnancy is induced by pregnancy, and its incidence can be as high as 10%, which is an important disease threatening maternal health. Mothers often suffer from hypertension, proteinuria, edema and other symptoms, and in severe cases it can cause convulsions, coma and even death.
N-Nitro-L-arginine methyl ester (L-NAME)
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Spontaneous abortion model 01
Spontaneous abortion (SA) is one of the common obstetrics and gynecology diseases, accounting for about 15% to 18% of all pregnancies. Clinically, early miscarriage is the most common cause of SA, accounting for about 60% of SA. Modern medicine believes that luteal insufficiency is one of the common causes of SA, and traditional Chinese medicine believes that kidney qi insufficiency, non-solidification of the flushing period, weakness of the spleen qi, and loss of nourishment for the fetus are the main pathogenesis of SA, and it is often characterized as spleen deficiency, kidney deficiency, or deficiency of the spleen and kidneys.
Hydroxycarbamide
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Spontaneous abortion model 02
Spontaneous abortion (SA) is one of the common obstetrics and gynecology diseases, accounting for about 15% to 18% of all pregnancies. Clinically, early miscarriage is the most common cause of SA, accounting for about 60% of SA. Modern medicine believes that luteal insufficiency is one of the common causes of SA, and traditional Chinese medicine believes that kidney qi insufficiency, non-solidification of the flushing period, weakness of the spleen qi, and loss of nourishment for the fetus are the main pathogenesis of SA, and it is often characterized as spleen deficiency, kidney deficiency, or deficiency of the spleen and kidneys.
Reserpine
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