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Medicine added to Diets
Diet Introduction
Product code
Remark
Doxycycline，DOX
Mouse gene expression system (Tet-based) has been widely used in experimental research. This system uses Doxycycline (tetracycline analogue, also known as doxycycline) to reversibly turn the target protein expression on and off freely, which is very convenient to observe the phenotypic changes of mice at any stage of development. Moreover, the controlled switching of genes can effectively avoid gene silencing after passage of transgenic mice caused by continuous gene expression.
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Tamoxifen
Tamoxifen (ICI 47699) is an orally effective, selective estrogen receptor regulator (SERM) that blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells. Tamoxifen is a potent Hsp90 activator that enhances the activity of the Hsp90 chaperone ATPase. Tamoxifen was also effective in inhibiting infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.1 μM and 1.8 μM, respectively. Tamoxifen can activate autophagy and induce apoptosis. Tamoxifen also induced gene knockout in CreER(T2) transgenic mice.
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Ranitidine
Ranitidine is a potent, selective, orally active histamine H2 receptor antagonist with an IC50 of 3.3 μM that inhibits gastric secretion. Ranitidine hydrochloride is also a weak inhibitor of CYP2C19 and CYP2C9.
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Trimethoprim
Trimethoprim is an antibiotic and an orally active dihydrofolate reductase inhibitor. Trimethoprim is active against a variety of Gram-positive and Gram-negative aerobic bacteria. Trimethoprim can be used in the study of urinary tract infections, Shigellosis and pneumocystis pneumonia. Trimethoprim combined with zinc inhibited the infection of chicken embryos by Influenza A virus.
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Metformin
Metformin (1, 1-dimethylbiguanide) inhibits the mitochondrial respiratory chain in the liver, resulting in AMPK activation and enhanced insulin sensitivity, which can be used in the study of type 2 diabetes. Metformin can cross the blood-brain barrier and induce autophagy.
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Sulfadiazine
Sulfadiazine is an antibiotic with antimalarial activity that can be used in studies of toxoplasmosis
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PLX3397
Pexidartinib (PLX-3397) is a potent, orally active, selective ATP-competitive colony stimulating factor 1 (CSF1R or M-CSFR) and c-Kit inhibitor with IC50 values of 20 and 10 nM, respectively. Pexidartinib (PLX-3397) is 10-100 times more selective to c-Kit and CSF1R than other related kinases, such as FLT3, KDR (VEGFR2), LCK, FLT1 (VEGFR1), and NTRK3 (TRKC). The IC50 values are 160,350,860,880, and 890 nM, respectively. Pexidartinib (PLX-3397) can induce apoptosis and has antitumor activity
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PLX5622
PLX5622 is a highly selective, blood-brain barrier transmissible, orally effective CSF1R inhibitor that can be used for expanded and specific microglial clearance before and during disease progression. PLX5622 has good pharmacological properties. PLX5622 is mostly used as a free-diet feed (HY-114153C).
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Adenine
Adenine (6-Aminopurine) is a purine that is one of the four bases of DNA nucleic acid. Adenine is a chemical component of DNA and RNA. Adenine plays an important role in cellular respiration, the formation of ATP, coenzyme factors NAD and FAD, and protein synthesis. After Adenine is metabolized by the liver, dihydroxyadenine, which is insoluble in water, is deposited in the kidney, which can cause retrorenal obstruction and affect uric acid excretion, thus causing kidney injury.
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Uric Acid
Uric acid, a scavenger of oxygen radicals, is a very important antioxidant that helps maintain stable blood pressure and fights oxidative stress. Uric acid removes reactive oxygen species (ROS), such as singlet oxygen and peroxynitrite, and inhibits lipid peroxidation.
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