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Hyperuricemia Model
Elevated uric acid levels can lead to crystal deposition and may cause gout, urolithiasis, and urate nephropathy. Ethambutol can increase uric acid levels by reducing renal uric acid clearance, ultimately leading to hyperuricemia.
Ethambutol
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Aplastic anemia model
Aplastic anemia (AA) is a syndrome of bone marrow hematopoietic failure caused by multiple factors, characterized by a decrease in whole blood cells. Busulfan can cause damage to hematopoietic stem cells in model animals, resulting in a significant reduction in the number of hematopoietic stem cells and a slower natural recovery. This model is suitable for research on drug treatment and screening for aplastic anemia.
Busulfan
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Leukopenia model
Leukopenia, a condition in which the peripheral blood white blood cell count is persistently below normal, is one of the common blood disorders, and cyclophosphamide can lead to bone marrow suppression, in which leukopenia is more common.
Cyclophosphamide
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