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Model Introduction
Medicine added to Diets
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Aortic dissection model
Aortic dissection (AD) is a critical and severe condition in clinical practice. It is caused by multiple factors that tear the intima and partial media of the aorta, which are then impacted by intravascular blood flow and separated along the longitudinal axis to form a connected or disconnected true and false lumen of the aortic wall. β-aminopropionitrile (BAPN) can be added to the feed in combination with angiotensin II (Ang II) to induce establishment.
β-Aminopropionitrile (BAPN)
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Myocardial fibrosis model
Trimethylamine N-oxide (TMAO) is a gut microbiota derived metabolite of dietary choline and other trimethylamine containing nutrients, which is associated with poor prognosis of coronary heart disease. TMAO plays an important role in cardiac fibrosis after myocardial infarction (MI).
Trimethylamine N-oxide (TMAO)
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Hypotension model
The hypotension model uses feed containing reserpine to feed animals to form an overall hypotensive state, which is more relevant to clinical practice and suitable for efficacy evaluation and mechanism exploration.
Reserpine
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Hypertension model
Hypertension (HTN), also known as elevated blood pressure, is a phenomenon in which the pressure on the blood vessel wall caused by the flow of blood in the blood vessels remains higher than normal. By adding dexamethasone to the feed, a hypertension model can be established.
Dexamethasone
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Cirrhotic portal hypertension model
Thioacetamide (TAA) is a hepatotoxic substance that can reduce the content of P450 in liver cell nuclei, inhibit respiratory metabolic enzyme activity in liver cell nuclei, increase liver cell DNA synthesis and mitosis, and lead to cirrhosis. The liver cirrhosis model produced by this method has histological changes similar to human liver cirrhosis, with significantly increased portal vein pressure and a certain degree of portal body traffic diversion.
Thioacetamide (TAA)
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Dilated cardiomyopathy model
Dilated cardiomyopathy (DCM) is a serious cardiovascular disease characterized by myocardial cell necrosis and interstitial fibrosis, as well as cardiac enlargement, arrhythmia, congestive heart failure, and even sudden death.
Furazolidone
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