Bladder cancer model 01

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The main risk factors for bladder cancer are environmental carcinogens, such as nitrosamines such as n-butyl-N -(4-hydroxybutyl) nitrosamines (BBN). BBN will undergo oxidation and glucuronic acid conjugation after entering the body. Its oxidized product N-butyl-N -(3-carboxypropyl) -nitrosamine (BCPN) forms adducts with the DNA of urothelium cells, thereby inducing tumorigenosis. Therefore, long-term exposure to BBN is a routine method for inducing bladder cancer in rodent models.

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